murine anti-tweak antibody p2d10 Search Results


p2d10  (Biogen Inc)
86
Biogen Inc p2d10
P2d10, supplied by Biogen Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/murine+anti-tweak+antibody+p2d10/anti+p2d10/bio_rxiv__64898__2025__11__30__691475-58-11-18
Average 86 stars, based on 1 article reviews
p2d10 - by Bioz Stars, 2026-10
86/100 stars
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anti fn14 mab  (OriGene)
90
OriGene anti fn14 mab
FIGURE 5. Detection of Fn-14 in the brain of control and MS cases. (A) Immunostaining with <t>anti-Fn14</t> antibody shows that the normal white matter is largely negative for this molecule; the inset highlights the occasional finding of isolated cells with an astrocytic morphology that are strongly immunoreactive for Fn14. (BYG) Immunostaining performed in highly inflammatory brains from secondary progressive multiple sclerosis (SPMS) cases with ectopic follicles. (B) Immunostaining reveals the presence of several Fn14+ reactive astrocytes at the edge of a white matter lesion; the inset shows one of the rare Fn14+ cells with a microglia-like morphology identified in the same lesion. (C) Some astrocytes are Fn14+ in a subpial lesion close to an ectopic follicle. (D, E) In 2 different SPMS cases with marked meningeal inflammation, Fn14 immunoreactivity is present on some neuronal cell bodies (D) and processes (E). (F, G) Double immunofluorescence staining with anti-Fn14 monoclonal antibody (green) and anti-NF 200 (red) demonstrates Fn14 immunoreactivity on the membrane of neurofilament+ axons. Original magnification: (A, B, D) 500; ([C] and inset in [A]) 1,000. Scale bars = (E) 50 Km; (F) 20 Km.
Anti Fn14 Mab, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/murine+anti-tweak+antibody+p2d10/TWEAKR+(TNFRSF12A)+(NM_016639)+Human+3'+UTR+Clone/10__1097_slash_nen__0b013e31818dab90-57-22-26
Average 90 stars, based on 1 article reviews
anti fn14 mab - by Bioz Stars, 2026-10
90/100 stars
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anti cleaved caspase 3 rabbit polyclonal ab  (Cell Signaling Technology Inc)
99
Cell Signaling Technology Inc anti cleaved caspase 3 rabbit polyclonal ab
FIGURE 5. Detection of Fn-14 in the brain of control and MS cases. (A) Immunostaining with <t>anti-Fn14</t> antibody shows that the normal white matter is largely negative for this molecule; the inset highlights the occasional finding of isolated cells with an astrocytic morphology that are strongly immunoreactive for Fn14. (BYG) Immunostaining performed in highly inflammatory brains from secondary progressive multiple sclerosis (SPMS) cases with ectopic follicles. (B) Immunostaining reveals the presence of several Fn14+ reactive astrocytes at the edge of a white matter lesion; the inset shows one of the rare Fn14+ cells with a microglia-like morphology identified in the same lesion. (C) Some astrocytes are Fn14+ in a subpial lesion close to an ectopic follicle. (D, E) In 2 different SPMS cases with marked meningeal inflammation, Fn14 immunoreactivity is present on some neuronal cell bodies (D) and processes (E). (F, G) Double immunofluorescence staining with anti-Fn14 monoclonal antibody (green) and anti-NF 200 (red) demonstrates Fn14 immunoreactivity on the membrane of neurofilament+ axons. Original magnification: (A, B, D) 500; ([C] and inset in [A]) 1,000. Scale bars = (E) 50 Km; (F) 20 Km.
Anti Cleaved Caspase 3 Rabbit Polyclonal Ab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/murine+anti-tweak+antibody+p2d10/Caspase-3+Antibody/10__1097_slash_nen__0b013e31818dab90-57-98-103
Average 99 stars, based on 1 article reviews
anti cleaved caspase 3 rabbit polyclonal ab - by Bioz Stars, 2026-10
99/100 stars
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Image Search Results


FIGURE 5. Detection of Fn-14 in the brain of control and MS cases. (A) Immunostaining with anti-Fn14 antibody shows that the normal white matter is largely negative for this molecule; the inset highlights the occasional finding of isolated cells with an astrocytic morphology that are strongly immunoreactive for Fn14. (BYG) Immunostaining performed in highly inflammatory brains from secondary progressive multiple sclerosis (SPMS) cases with ectopic follicles. (B) Immunostaining reveals the presence of several Fn14+ reactive astrocytes at the edge of a white matter lesion; the inset shows one of the rare Fn14+ cells with a microglia-like morphology identified in the same lesion. (C) Some astrocytes are Fn14+ in a subpial lesion close to an ectopic follicle. (D, E) In 2 different SPMS cases with marked meningeal inflammation, Fn14 immunoreactivity is present on some neuronal cell bodies (D) and processes (E). (F, G) Double immunofluorescence staining with anti-Fn14 monoclonal antibody (green) and anti-NF 200 (red) demonstrates Fn14 immunoreactivity on the membrane of neurofilament+ axons. Original magnification: (A, B, D) 500; ([C] and inset in [A]) 1,000. Scale bars = (E) 50 Km; (F) 20 Km.

Journal: Journal of Neuropathology & Experimental Neurology

Article Title: Expression of TWEAK and Its Receptor Fn14 in the Multiple Sclerosis Brain: Implications for Inflammatory Tissue Injury

doi: 10.1097/nen.0b013e31818dab90

Figure Lengend Snippet: FIGURE 5. Detection of Fn-14 in the brain of control and MS cases. (A) Immunostaining with anti-Fn14 antibody shows that the normal white matter is largely negative for this molecule; the inset highlights the occasional finding of isolated cells with an astrocytic morphology that are strongly immunoreactive for Fn14. (BYG) Immunostaining performed in highly inflammatory brains from secondary progressive multiple sclerosis (SPMS) cases with ectopic follicles. (B) Immunostaining reveals the presence of several Fn14+ reactive astrocytes at the edge of a white matter lesion; the inset shows one of the rare Fn14+ cells with a microglia-like morphology identified in the same lesion. (C) Some astrocytes are Fn14+ in a subpial lesion close to an ectopic follicle. (D, E) In 2 different SPMS cases with marked meningeal inflammation, Fn14 immunoreactivity is present on some neuronal cell bodies (D) and processes (E). (F, G) Double immunofluorescence staining with anti-Fn14 monoclonal antibody (green) and anti-NF 200 (red) demonstrates Fn14 immunoreactivity on the membrane of neurofilament+ axons. Original magnification: (A, B, D) 500; ([C] and inset in [A]) 1,000. Scale bars = (E) 50 Km; (F) 20 Km.

Article Snippet: Air-dried acetone-fixed 10-Km-thick cryosections were immunostained with the following antibodies (Abs): antiTWEAK monoclonal Ab (mAb) (clone P2D10; Biogen Idec, Cambridge, MA), and anti-Fn14 mAb (clone ITEM4; Acris Antibodies, Herford, Germany), anti-Iba-1 (ionized calcium binding adapter molecule-1) rabbit polyclonal Ab (a kind gift of Dr Y. Imai, Tokyo, Japan) for macrophages/microglia; anti-CD20 for B cells (Immunotech, Marseille, France); antiimmunoglobulin A, M, G polyclonal Ab (Dako, Carpinteria, CA) for plasma cells, anti-HLA-DR mAb (CR3/43, Dako), anti-MOG mAb (Serotec, Oxford, United Kingdom) for myelin staining, anti-glial fibrillary acidic protein rabbit polyclonal antibody (Dako) and mAb (Biogenex, San Ramon, CA) for astrocytes, anti-cleaved caspase-3 rabbit polyclonal Ab (Cell Signaling Technology, Boston, MA) to stain apoptotic cells; anti-CD31 mAb for endothelial cells (Dako), anti-laminin rabbit polyclonal Ab for the basal membrane (Dako), and anti-neurofilament (200 kd) rabbit polyclonal antibody for neurons (DBA, Segrate, Milan, Italy).

Techniques: Control, Immunostaining, Isolation, Staining, Membrane

FIGURE 6. TWEAK and Fn14 gene expression in control and MS cortex. TWEAK (A) and Fn14 (B) messenger RNA (mRNA) was quantitated by real-time reverse transcription-polymerase chain reaction in cortical samples dissected from brains of control (n = 9) and multiple sclerosis (MS) cases (n = 16). Data are expressed as mRNA levels normalized to glyceraldehyde-3- phosphate dehydrogenase relative to a sample of pooled control cases used for calibration. Dots represent values for each control or MS case analyzed; bars represent median values. Values of p were calculated with Mann-Whitney U test.

Journal: Journal of Neuropathology & Experimental Neurology

Article Title: Expression of TWEAK and Its Receptor Fn14 in the Multiple Sclerosis Brain: Implications for Inflammatory Tissue Injury

doi: 10.1097/nen.0b013e31818dab90

Figure Lengend Snippet: FIGURE 6. TWEAK and Fn14 gene expression in control and MS cortex. TWEAK (A) and Fn14 (B) messenger RNA (mRNA) was quantitated by real-time reverse transcription-polymerase chain reaction in cortical samples dissected from brains of control (n = 9) and multiple sclerosis (MS) cases (n = 16). Data are expressed as mRNA levels normalized to glyceraldehyde-3- phosphate dehydrogenase relative to a sample of pooled control cases used for calibration. Dots represent values for each control or MS case analyzed; bars represent median values. Values of p were calculated with Mann-Whitney U test.

Article Snippet: Air-dried acetone-fixed 10-Km-thick cryosections were immunostained with the following antibodies (Abs): antiTWEAK monoclonal Ab (mAb) (clone P2D10; Biogen Idec, Cambridge, MA), and anti-Fn14 mAb (clone ITEM4; Acris Antibodies, Herford, Germany), anti-Iba-1 (ionized calcium binding adapter molecule-1) rabbit polyclonal Ab (a kind gift of Dr Y. Imai, Tokyo, Japan) for macrophages/microglia; anti-CD20 for B cells (Immunotech, Marseille, France); antiimmunoglobulin A, M, G polyclonal Ab (Dako, Carpinteria, CA) for plasma cells, anti-HLA-DR mAb (CR3/43, Dako), anti-MOG mAb (Serotec, Oxford, United Kingdom) for myelin staining, anti-glial fibrillary acidic protein rabbit polyclonal antibody (Dako) and mAb (Biogenex, San Ramon, CA) for astrocytes, anti-cleaved caspase-3 rabbit polyclonal Ab (Cell Signaling Technology, Boston, MA) to stain apoptotic cells; anti-CD31 mAb for endothelial cells (Dako), anti-laminin rabbit polyclonal Ab for the basal membrane (Dako), and anti-neurofilament (200 kd) rabbit polyclonal antibody for neurons (DBA, Segrate, Milan, Italy).

Techniques: Gene Expression, Control, Reverse Transcription, Polymerase Chain Reaction, MANN-WHITNEY